Enantio- and diastereoselective construction of vicinal C(sp3) centres via nickel-catalysed hydroalkylation of alkenes

In drug discovery, the proportion of aliphatic carbons (C(sp3)) and presence chiral in organic molecules are positively correlated to their chance clinical success. Although methods exist for synthesis C(sp3)-rich molecules, they often limited scope, have poor modularity or unsuitable stereoselective using racemic reagents. The stereocontrol vicinal C(sp3) centres is a particular challenge. Here we describe nickel-catalysed enantio- diastereoselective hydroalkylation internal alkenes with alkyl bromides selectively form one four possible stereoisomers. Because its general modular character, high functional group tolerance, expect this approach wide applications molecules. Simultaneous stereochemical control two stereocentres from reaction partners challenging. Now, achieved cross-coupling bromides.